Macrophages in the Lungs of SCID Mice Alveolar Assessment of Reconstituted Normal Morphologic Detection and Functional
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Airway delivery of interferon‐γ overexpressing macrophages confers resistance to Mycobacterium avium infection in SCID mice
Mycobacterium avium (M. avium) causes significant pulmonary infection, especially in immunocompromised hosts. Alveolar macrophages (AMs) represent the first line of host defense against infection in the lung. Interferon gamma (IFN-γ) activation of AMs enhances in vitro killing of pathogens such as M. avium We hypothesized that airway delivery of AMs into the lungs of immunodeficient mice infect...
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The role of alveolar macrophages in the production of granulocyte/ macrophage colony-stimulating factor(s) by the rat lung was investigated. Lavaged lungs, when incubated at proper weight per volume of culture medium, produced the same amount of colony-stimulating factor as unlavaged ones. Both lavaged and unlavaged lungs produced similar types of colony-stimulating factor (s). Prolonged i...
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The importance of endogenous interleukin 1 (II.-1) in resistance to Pneumocystis carinii infection was examined in a SCID mouse model. Naturally acquired pulmonary infection of P. carinii in SCID mice was completely cleared by reconstitution of the infected mice with immunocompetent spleen cells. I1:1 activity in the lung homogenate supernatant of these mice increased significantly after recons...
متن کاملTHE ROLE OF B-CELLS IN THE DEVELOPMENT OF IMMUNITY TO CRYPTOSPORIDIUM INFECTION
Studies have shown that symptomatic improvement of cryptosporidiosis in immunocompromised patients is possible following treatment with" hyperimmune" colostrum containing anti-sporozoite antibodies from cattle immunized with Cryptosporidium parvum antigens. The contribution to immunity of antibodies developed during Cryptosporidium infection is unclear, however. Previously, we showed that ...
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تاریخ انتشار 2002